Major Quit-Smoking Study: Vaping is Twice as Effective as NRT

Vaping skeptics question the efficacy of e-cigarettes for smoking cessation, often citing the lack of clinical trials proving a benefit to smokers. Randomized trials are usually used to test drugs intended to treat specific conditions. They typically compare two or more therapies with each other, or test drugs against a control group that receives a placebo.

The problem with translating drug research to a consumer product like e-cigarettes is that the strict protocols of a drug trial (all participants use a certain drug at a certain dose and interval) may not translate to products that succeed by offering a wide range of possibilities to users. After all, vaping isn’t a cure for a disease, but rather a less risky consumption choice that competes with cigarettes.

There have been large smoking cessation trials using e-cigarettes before. However, the most recent were from 2014, and the data in those studies were collected even earlier, from trials of first generation cigalike products. Nevertheless, even though those studies used primitive vaping devices, the results showed cessation success on par with nicotine replacement therapy (NRT) products.

Now a study led by Prof. Peter Hajek of Queen Mary University of London describes a randomized trial comparing smokers attempting to quit using a vaping product with others using NRT. And even though the study participants who attempted to quit by vaping were given the choice of just one product, the results were impressive.

After one year, 18 percent of the vaping group was abstinent from cigarettes — almost twice as many as those who used the pharmaceutical nicotine products (9.9 percent). (Abstinence was verified with a carbon monoxide test, which shows evidence of recent smoking.)

“The figure may sound low,” notes Prof. Hajek, “but…if they were quitting on their own, the quit rate would be about 3 percent.” That makes using vapes to quit (with proper advice and support) about six times more effective than quitting with no help.

Other researchers involved in the study came from Queen Mary and other British universities, and from an American institution. The study was published in the New England Journal of Medicine. The journal was apparently so embarrassed about the positive results that it commissioned not one but two accompanying editorials slamming e-cigarettes, one offering questionable advice to doctors (insist smokers try and fail with NRT first; use low nicotine vaping products), and the other advocating for a vaping flavor ban.

The trial divided 886 smokers into two groups. The participants in one group got their choice of NRT products like nicotine patches, gum, lozenges, mouth strips, inhalers and nasal spray. Additional NRT products were provided free for three months, and the participants were allowed to use multiple products. The other group was given a simple all-in-one vape kit (the Aspire One Kit or the Innokin One Kit 2016) and one or two 10 mL bottles of 18 mg/mL tobacco-flavored e-liquid. The vaping group was instructed how to use and refill the device, and encouraged to buy additional e-liquid from a vape shop where they could choose other flavors (or even other devices). Both groups had in-person counseling sessions weekly for the first month.



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